Histone H2B type 1-J

Also known as: Histone H2B.1, Histone H2B.r, H2BC11, P06899

Histone H2B type 1-J (H2BC11) is a core structural component of the nucleosome, the fundamental unit of chromatin. As a histone protein, it forms part of the octamer—composed of two copies each of H2A, H2B, H3, and H4—around which approximately 147 base pairs of DNA are wrapped. This packaging compacts genomic DNA into the nucleus and regulates access to DNA for processes such as transcription, replication, and repair. Post-translational modifications of H2B, including ubiquitination and acetylation, further modulate chromatin dynamics and gene expression. Currently, no peer-reviewed research publications specifically addressing Histone H2B type 1-J are indexed in PubMed, reflecting its experimental status. General histone H2B research has established its role in nucleosome stability and epigenetic regulation, but subtype-specific functional data for H2B type 1-J remain absent. Its designation as "experimental" indicates that its unique biological properties or therapeutic potential have not been characterized in controlled studies. Given the lack of published evidence, no clinical applications or translational relevance can be attributed to Histone H2B type 1-J at this time. Further investigation is required to determine its specific contributions to chromatin biology or disease states. For research purposes only — not medical advice.

Key data

Mechanism of action

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

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