Beta-defensin 114

Also known as: Beta-defensin 14, Defensin, beta 114, DEFB114, Q30KQ6

Beta-defensin 114 (DEFB114) is an antimicrobial peptide belonging to the beta-defensin family, characterized by a conserved six-cysteine motif that forms three disulfide bridges. Its mechanism of action involves salt-sensitive disruption of microbial membranes, exhibiting broad-spectrum activity against Gram-negative bacteria (e.g., *Escherichia coli*), Gram-positive bacteria (e.g., *Staphylococcus aureus*), and fungi (e.g., *Candida albicans*). The salt sensitivity suggests its antimicrobial efficacy may be modulated by ionic conditions, a common feature among defensins that can influence activity in physiological environments. Current research on DEFB114 remains at an experimental stage, with limited published data. The single PubMed reference indicates preliminary characterization of its antimicrobial properties, but no in vivo or clinical studies have been reported. Key findings focus on its in vitro activity spectrum and salt-dependent behavior, which may inform future investigations into its role in host defense and potential therapeutic applications. Clinical relevance is not yet established due to the scarcity of translational research. Further studies are needed to evaluate its safety, stability, and efficacy in relevant models before considering applications in infectious disease management. For research purposes only — not medical advice.

Key data

Mechanism of action

Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality

Research & studies

Frequently asked questions

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