Urotensin-2B
experimentalAlso known as: Urotensin II-related peptide, Urotensin IIB, Urotensin-2 domain-containing protein, UTS2B, Q765I0
Urotensin-2B (UTS2B), also known as urotensin II-related peptide, is a cyclic neuropeptide structurally related to urotensin II. Its primary mechanism of action involves potent vasoconstriction mediated through binding to the G protein-coupled urotensin II receptor (UTS2R). Activation of this receptor triggers intracellular calcium mobilization and downstream signaling pathways, leading to smooth muscle contraction in vascular and non-vascular tissues. UTS2B exhibits comparable or greater vasoconstrictor potency than urotensin II in certain vascular beds, suggesting a distinct physiological role. Current experimental research on UTS2B is limited, with only three indexed PubMed references. Preliminary findings indicate its expression in the central nervous system and peripheral tissues, including the cardiovascular system. Studies have demonstrated its ability to induce contraction in isolated arterial rings and modulate ion transport in renal tissues. However, no comprehensive in vivo or clinical data exist, and its precise physiological or pathological functions remain poorly characterized. Given the scarcity of research, UTS2B has no established clinical relevance. Its potential involvement in hypertension, heart failure, or renal disorders is speculative and requires further investigation. The peptide remains an experimental tool for studying urotensinergic signaling. For research purposes only — not medical advice.
Key data
MNKILSSTVCFGLLTLLSVLSFLQSVHGRPYLTQGNEIFPDKKYTNREELLLALLNKNFDFQRPFNTDLALPNKLEELNQLEKLKEQLVEEKDSETSYAVDGLFSSHPSKRACFWKYCVMechanism of action
Potent vasoconstrictor
Research & studies
Uts2b expression in vagal afferent neurons is microbiota-dependent.; Uts2b is induced by the FFAR3 agonist AR420626 and by cholecystokinin.; Most Uts2b-expressing neurons express CCK-A receptor, comprising ~25% of CCK-A-positive neurons.; Uts2b-expressing nerve fibers directly contact CCK-expressing enteroendocrine cells.
JNC neurons activated an injury response program after LPS exposure, increasing expression of Cckbr and Gpr151.; Unique JNC-specific transcripts (TMC3, urotensin 2B) were identified, minimally expressed in other ganglia and organs.; Acute lung injury rapidly induces a nerve injury-related state in vagal sensory neurons, altering excitability.
UTS2B defines a new enteroendocrine cell type in the gut.; UTS2B inhibits GLP-1 secretion through SSTR5, not its cognate receptor UTS2R.; Circulating UTS2B levels are regulated by starvation in mice.; UTS2B administration modulates blood glucose and GLP-1/insulin in vivo.
Frequently asked questions
What is Urotensin-2B?
Urotensin-2B (UTS2B), also known as urotensin II-related peptide, is a cyclic neuropeptide structurally related to urotensin II. Its primary mechanism of action involves potent vasoconstriction mediated through binding to the G protein-coupled urotensin II receptor (UTS2R). Activation of this receptor triggers intracel
How does Urotensin-2B work?
Potent vasoconstrictor
What is the research status of Urotensin-2B?
Urotensin-2B is currently classified as experimental, with 3 research references on record. This is for research purposes only and is not medical advice.
What is the molecular weight of Urotensin-2B?
Urotensin-2B has a molecular weight of approximately 13749 g/mol.
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