Tachykinin-3

Also known as: ZNEUROK1, TAC3, Q9UHF0

**Mechanism of Action** Tachykinin-3 (TAC3), encoded by the *TAC3* gene, is a member of the tachykinin peptide family, which includes substance P and neurokinin A. It primarily acts as an agonist at neurokinin-3 receptors (NK3R), a G-protein-coupled receptor expressed in the central nervous system and peripheral tissues. Activation of NK3R triggers phospholipase C-mediated intracellular signaling, leading to calcium mobilization and modulation of neuronal excitability. Tachykinin-3 is involved in neurotransmission, smooth muscle contraction, vasodilation, and secretagogue activity, with particular roles in regulating reproductive function, stress responses, and pain processing. **Key Research Findings** Preclinical studies demonstrate that TAC3 signaling is critical for gonadotropin-releasing hormone (GnRH) secretion and reproductive maturation, as mutations in *TAC3* or its receptor cause hypogonadotropic hypogonadism in humans. Animal models show that TAC3 modulates dopaminergic and serotonergic pathways, influencing anxiety-like behaviors and locomotor activity. Additionally, TAC3 has been implicated in neurogenic inflammation and visceral hypersensitivity, with NK3R antagonists showing efficacy in reducing stress-induced colonic motility in rodent models. Current research remains experimental, with 27 PubMed-indexed studies exploring its roles in neuroendocrine regulation, pain, and psychiatric disorders. **Clinical Relevance** While TAC3 is not yet a therapeutic target, its involvement in reproductive disorders and stress-related conditions positions it as a candidate for drug development. NK3R antagonists are under investigation for treating hot flashes, schizophrenia, and irritable bowel syndrome. However, no TAC3-based therapies have advanced to clinical approval. For research purposes only — not medical advice.

Key data

Mechanism of action

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles

Research & studies

Frequently asked questions

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