Pinealon
experimentalAlso known as: EDR peptide, Glu-Asp-Arg
Pinealon (Glu-Asp-Arg, EDR) is a synthetic tripeptide classified as a Khavinson bioregulator, proposed to modulate neuronal gene expression and protect against oxidative stress. Its mechanism involves binding to DNA regulatory regions, thereby influencing transcription of genes associated with neuronal differentiation, synaptic plasticity, and antioxidant defense. Preclinical studies suggest Pinealon may upregulate superoxide dismutase and catalase activity, reducing reactive oxygen species accumulation in neural tissues. Key research findings from 15 PubMed-indexed studies indicate Pinealon enhances cognitive function and neuronal survival in rodent models of aging and neurodegeneration. In vitro, it promotes neurite outgrowth and reduces apoptosis in hippocampal neurons exposed to oxidative insults. However, no large-scale human trials have been published, and most evidence remains limited to cell culture and animal experiments. Clinical relevance is currently speculative. Pinealon has not been approved by regulatory agencies for any therapeutic indication. Its potential applications in age-related cognitive decline or neuroprotection require rigorous validation through controlled human studies. For research purposes only — not medical advice.
Key data
C15H26N6O8Research & studies
Both pinealon and vesugen had significant anabolic effects and improved central nervous system activity.; Vesugen showed a more visible geroprophylactic effect than pinealon.; Prooxidant activity was detected via chemiluminescence, and CD34+ hematopoietic stem cells decreased.; The peptides did not affect chromatin condensation, indicating safety at the nuclear genetic level.
Frequently asked questions
What is Pinealon?
Pinealon (Glu-Asp-Arg, EDR) is a synthetic tripeptide classified as a Khavinson bioregulator, proposed to modulate neuronal gene expression and protect against oxidative stress. Its mechanism involves binding to DNA regulatory regions, thereby influencing transcription of genes associated with neuronal differentiation,
How does Pinealon work?
Khavinson bioregulator tripeptide (EDR) proposed to modulate neuronal gene expression and protect against oxidative stress.
What is the research status of Pinealon?
Pinealon is currently classified as experimental, with 15 research references on record. This is for research purposes only and is not medical advice.
What is the molecular weight of Pinealon?
Pinealon has a molecular weight of approximately 418.4 g/mol (formula C15H26N6O8).
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