Hexarelin

Single daily doses of 25, 50, and 100 µg/kg hexarelin dose-dependently and significantly increased RGC survival at 7 days after ONT (51.2%, 62.4%, 68.5%, and 74.6% for saline, 25, 50, and 100 µg/kg, respectively).; Twice-daily doses of 100 and 150 µg/kg hexarelin further promoted RGC survival to 91.4% and 109.2%, respectively, compared to 72.9% with saline.; 150 µg/kg hexarelin administered twice daily was optimal for RGC survival after ONT.

Hexarelin pretreatment reduced tubular necrosis, improved renal function, and inhibited apoptosis in I/R-induced AKI rats.; Hexarelin downregulated pro-apoptotic proteins (Caspase-3, Bax, Bad) and upregulated anti-apoptotic Bcl-2.; Molecular docking showed strong binding affinity between Hexarelin and MDM2, suggesting a mechanism via MDM2/p53 pathway.; Hexarelin suppressed MDM2 and p53 expression in both in vivo and in vitro experiments.

Hexarelin decreased infrarenal aorta diameter in elastase-induced AAA mice.; Hexarelin rescued smooth muscle cell contractile phenotype by increasing α-SMA and decreasing MMP2.; Hexarelin inhibited NLRP3 inflammasome activation, IL-18 production, and inflammatory cell infiltration.; Hexarelin suppressed NF-κB signaling pathway, a key initiator of inflammatory response.

Chitosan and EDTA increased the mucosal permeability of both enalaprilat and hexarelin to a similar extent.; Paracellular enhancers may have greater potential for increasing intestinal absorption of low-molecular-mass hydrophilic peptides than transcellular enhancers.; Mucosal blood-to-lumen flux of 51Cr-EDTA was increased by paracellular enhancers and by luminal hypotonicity.; Luminal hypotonicity did not affect lumen-to-blood transport of enalaprilat or hexarelin, suggesting it primarily affects paracellular transport in the crypt region.

Hexarelin in combination with morphine attenuates analgesic tolerance to morphine.; Co-administration of hexarelin and morphine increases the analgesic effect.; The ghrelin receptor antagonist [d-Lys3]-GHRP-6 has no significant analgesic activity on morphine tolerance.; GHS-R agonist hexarelin with morphine enhances antinociception and attenuates morphine tolerance.

Hexarelin decreased serum TC, TG and LDL-c and increased serum HDL-c in ApoE-/- mice.; Hexarelin attenuated atherosclerotic plaque and neointima formation compared with the AS group.; Hexarelin decreased aortic CD68 and LOX-1 expression, increased GHSR expression, and suppressed ox-LDL uptake and NF-κB activation in aorta and RAW264.7 macrophages.; The findings support hexarelin as a potential anti-atherosclerosis drug.

Hexarelin suppressed angiotensin-II-induced hypertrophy, oxidative stress, and apoptosis in H9C2 cells.; Hexarelin enhanced autophagy in hypertrophic H9C2 cells.; Inhibition of autophagy with 3-methyladenine abolished hexarelin's anti-hypertrophic and protective effects.; Hexarelin's autophagy-dependent protection involves inhibition of mTOR phosphorylation.

STZ-diabetic rats showed significantly reduced total, pulsatile, basal, and per-burst GH secretion, along with increased fasting FFAs and decreased IGF-1 versus controls.; Hexarelin treatment significantly increased total, pulsatile, and basal GH secretion in STZ-rats, but not the mass of GH secreted per burst.; Hexarelin significantly decreased fasting FFAs in STZ-rats, while IGF-1 suppression was maintained.; No significant elevation in GH secretion was observed in the hexarelin-treated control group.

What is Hexarelin?

**Mechanism of Action** Hexarelin is a synthetic hexapeptide belonging to the growth hormone-releasing peptide (GHRP) family. It acts as a potent agonist at the ghrelin receptor (GHS-R1a), stimulating growth hormone (GH) secretion via the pituitary and hypothalamus. However, its cardioprotective effects are mediated th

How does Hexarelin work?

Potent GHRP-family ghrelin receptor agonist with studied cardioprotective effects independent of GH release.

What is the research status of Hexarelin?

Hexarelin is currently classified as clinical trials, with 291 research references on record. This is for research purposes only and is not medical advice.

What is the molecular weight of Hexarelin?

Hexarelin has a molecular weight of approximately 887 g/mol (formula C47H58N12O6).