Mechano Growth Factor (MGF)
preclinicalAlso known as: IGF-1Ec, MGF peptide
Mechano Growth Factor (MGF), also known as IGF-1Ec, is a splice variant of insulin-like growth factor-1 (IGF-1) that is upregulated in response to mechanical stress or muscle damage. Its mechanism of action involves binding to the IGF-1 receptor, which activates downstream signaling pathways such as PI3K/Akt, leading to enhanced proliferation and differentiation of muscle satellite cells. This process is critical for localized muscle repair and hypertrophy, distinguishing MGF from systemic IGF-1 isoforms by its rapid, tissue-specific expression following mechanical loading. Preclinical research has demonstrated that MGF administration or overexpression promotes muscle regeneration and attenuates atrophy in models of injury and aging. Studies in rodent models show increased satellite cell activation, myofiber cross-sectional area, and functional recovery post-crush injury. However, its effects are transient and context-dependent, with some evidence suggesting that chronic overexpression may lead to dysregulated growth or fibrosis. No human clinical trials have been conducted, and the peptide's stability and delivery remain challenges. Clinically, MGF has potential applications in treating muscle wasting disorders, sarcopenia, and sports injuries, but its use remains strictly preclinical. Due to the lack of human safety and efficacy data, MGF is not approved for therapeutic use. For research purposes only — not medical advice.
Key data
Research & studies
Endogenous MGF expression in neurogenic brain areas declined with age in control mice.; Constitutive MGF overexpression increased BrdU+ proliferative cells in the dentate gyrus and subventricular zone but did not alter post-mitotic neuron distribution.; Conditional MGF overexpression from 1 or 3 months of age increased proliferating cells and mature neurons in olfactory bulbs at 24 months, preserving olfactory function; no effect when started at 12 months.; In vitro, MGF increased the size and number of neurospheres from SVZ-derived neural stem cells.
Frequently asked questions
What is Mechano Growth Factor (MGF)?
Mechano Growth Factor (MGF), also known as IGF-1Ec, is a splice variant of insulin-like growth factor-1 (IGF-1) that is upregulated in response to mechanical stress or muscle damage. Its mechanism of action involves binding to the IGF-1 receptor, which activates downstream signaling pathways such as PI3K/Akt, leading t
How does Mechano Growth Factor (MGF) work?
Mechanically activated IGF-1 splice variant that activates muscle satellite cells for repair and hypertrophy.
What is the research status of Mechano Growth Factor (MGF)?
Mechano Growth Factor (MGF) is currently classified as preclinical, with 193 research references on record. This is for research purposes only and is not medical advice.
Related peptides
Truncated IGF-1 variant with high local potency and short half-life, studied for site-specific muscle growth.
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Long-acting IGF-1 analog with reduced IGFBP binding, prolonging activation of the IGF-1 receptor to drive muscle hypertrophy.
Soluble ActRIIB-Fc decoy receptor that sequesters myostatin and related ligands; trialed in muscular dystrophy before discontinuation.
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