Kisspeptin-10
clinical trialsAlso known as: KP-10, Metastin fragment
Kisspeptin-10 (KP-10), a decapeptide fragment of the metastin/kisspeptin-1 protein, acts as a potent agonist at the KISS1 receptor (KISS1R, GPR54). Its primary mechanism involves direct activation of hypothalamic gonadotropin-releasing hormone (GnRH) neurons, thereby serving as an upstream regulator of the entire reproductive hormone axis. By stimulating pulsatile GnRH secretion, KP-10 indirectly promotes luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release from the anterior pituitary, making it a critical modulator of puberty onset, fertility, and gonadal function. Key research findings from clinical trials demonstrate that exogenous KP-10 administration robustly elevates LH and, to a lesser extent, FSH levels in healthy adults, with effects dependent on dose and route of administration. Studies have shown its utility in diagnosing and treating hypothalamic amenorrhea, hypogonadotropic hypogonadism, and certain forms of infertility, as it can restore endogenous GnRH pulsatility. Additionally, KP-10 has been investigated for its role in metabolic regulation, with evidence linking kisspeptin signaling to energy balance and glucose homeostasis, though these applications remain exploratory. Clinically, KP-10 is being evaluated as a diagnostic tool for assessing hypothalamic-pituitary-gonadal axis integrity and as a therapeutic agent for conditions characterized by impaired GnRH secretion, such as functional hypothalamic amenorrhea. Its rapid onset and short half-life offer advantages over traditional gonadotropin therapies, though further trials are needed to establish optimal dosing, safety, and long-term efficacy. For research purposes only — not medical advice.
Key data
C63H83N17O14Research & studies
Kisspeptin-10 reduced body weight, blood glucose, and energy intake to normal diet levels in high-fat fed female mice.; In the ileum, kisspeptin-10 decreased crypt depth, restored villi length to ND levels, and increased the proportion of GIP-positive cells versus HFD mice and GLP-1-positive cells versus ND mice, while PYY immunoreactivity was unaltered.; Circulating GLP-1 and PYY were reduced to ND levels by kisspeptin-10, whereas plasma GIP was unchanged.; In the pancreas, kisspeptin-10 restored relative insulin area to ND levels, normalised glucagon radius and elevated glucagon-islet area, and increased beta-cell proliferation without altering beta-cell apoptosis.
Kp-10 expression was reduced in cortical tissue after MCAO, and its administration alleviated neurological deficits and reduced BBB permeability (14C-sucrose leakage).; Kp-10 treatment upregulated Claudin-10 expression in the post-stroke cortex and in OGD/R-exposed HBMVECs, reducing endothelial permeability.; Kp-10 decreased mitochondrial ROS, increased SOD activity, and upregulated Nrf2 expression in vitro.; Nrf2 knockdown abolished Kp-10's protective effects on endothelial permeability and Claudin-10 expression, indicating the Nrf2 pathway is essential.
CZGE penetrates intestinal and brain barriers after oral administration to target hypothalamic neurons.; Zn-Cur released from CZGE replaces excess Cu2+ via ion exchange, forming Cu-Cur and releasing Zn2+.; Cu-Cur reduces intracellular copper and neuroinflammation via the Nrf2/NLRP3 pathway, while Zn2+ inhibits extracellular copper influx by activating zinc transporter 1.; In WD mice, CZGE alleviates hypothalamic copper deposition, activates ERK1/2 phosphorylation, and repairs reproductive dysfunction by modulating the hypothalamic-pituitary-testicular axis.
Frequently asked questions
What is Kisspeptin-10?
Kisspeptin-10 (KP-10), a decapeptide fragment of the metastin/kisspeptin-1 protein, acts as a potent agonist at the KISS1 receptor (KISS1R, GPR54). Its primary mechanism involves direct activation of hypothalamic gonadotropin-releasing hormone (GnRH) neurons, thereby serving as an upstream regulator of the entire repro
How does Kisspeptin-10 work?
KISS1R agonist decapeptide that triggers hypothalamic GnRH release, upstream regulator of reproductive hormone axis.
What is the research status of Kisspeptin-10?
Kisspeptin-10 is currently classified as clinical trials, with 319 research references on record. This is for research purposes only and is not medical advice.
What is the molecular weight of Kisspeptin-10?
Kisspeptin-10 has a molecular weight of approximately 1302.4 g/mol (formula C63H83N17O14).
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