Adipotide
preclinicalAlso known as: FTPP, Prohibitin-TP01
**Mechanism of Action** Adipotide (FTPP, Prohibitin-TP01) is a proapoptotic peptidomimetic designed to selectively target and eliminate the blood supply of white adipose tissue (WAT). It binds to prohibitin, a protein overexpressed on the surface of endothelial cells in WAT vasculature, triggering apoptosis via mitochondrial dysfunction and caspase activation. This leads to localized vascular disruption, reduced blood flow, and subsequent adipocyte death, resulting in rapid fat loss without affecting lean tissue or other organs. **Key Research Findings** In preclinical primate studies (e.g., *Sci Transl Med* 2011), Adipotide induced significant, dose-dependent reductions in body weight (up to 11% over 4 weeks) and fat mass, primarily from visceral and subcutaneous WAT. Histological analysis confirmed adipocyte shrinkage and reduced vascular density in treated adipose tissue. Metabolic improvements included decreased fasting glucose and insulin levels. However, reversible renal tubular injury was observed at higher doses, limiting therapeutic margin. Only three PubMed-indexed studies exist, all in non-human models. **Clinical Relevance** Adipotide remains in preclinical development with no human trials to date. Its targeted mechanism offers potential for obesity treatment, particularly for metabolically harmful visceral fat. However, nephrotoxicity concerns and lack of human safety/efficacy data preclude clinical translation. Further optimization of dosing and delivery is required to mitigate off-target effects. For research purposes only — not medical advice.
Key data
C111H206N36O28S2Research & studies
KLA-PTNP reduced body weight and serum leptin levels in DIO mice, unlike the bioconjugate Adipotide.; KLA-PTNP decreased ectopic fat deposits in liver and muscle with elevated serum adiponectin and no hepatotoxicity.; Nanoparticle delivery was enhanced by multivalent active targeting and endosomal escape into adipose endothelial cells.
Adipotide's weight loss effects may stem from decreased food consumption.; The original study's proposed mechanism of vascular apoptosis is questioned.; Direct effects on feeding behavior could explain the results.
Adipotide treatment caused targeted apoptosis within blood vessels of white adipose tissue.; Treatment resulted in rapid weight loss and improved insulin resistance in obese monkeys.; MRI and dual-energy x-ray absorptiometry confirmed marked reduction in white adipose tissue.; Optimal doses caused predictable and reversible changes in renal proximal tubule function across three monkey species.
Frequently asked questions
What is Adipotide?
**Mechanism of Action** Adipotide (FTPP, Prohibitin-TP01) is a proapoptotic peptidomimetic designed to selectively target and eliminate the blood supply of white adipose tissue (WAT). It binds to prohibitin, a protein overexpressed on the surface of endothelial cells in WAT vasculature, triggering apoptosis via mitocho
How does Adipotide work?
Proapoptotic peptidomimetic that targets the blood supply of white adipose tissue, causing fat reduction in primate studies.
What is the research status of Adipotide?
Adipotide is currently classified as preclinical, with 3 research references on record. This is for research purposes only and is not medical advice.
What is the molecular weight of Adipotide?
Adipotide has a molecular weight of approximately 2557.2 g/mol (formula C111H206N36O28S2).
Related peptides
Once-daily acylated GLP-1 receptor agonist for type 2 diabetes and chronic weight management.
Long-acting GLP-1 receptor agonist that improves glycemic control, slows gastric emptying, and reduces appetite.
Exendin-4-based GLP-1 receptor agonist from Gila monster venom; first-in-class incretin mimetic.
Dual GIP/GLP-1 receptor agonist delivering potent glucose lowering and weight reduction.
Once-weekly GLP-1 receptor agonist fused to an IgG4 Fc fragment for extended half-life.
Short-acting exendin-4-based GLP-1 receptor agonist with pronounced gastric-emptying delay.
Build on Adipotide data programmatically
Structured peptide data, semantic search, and AI summaries via one API.
Get a free API key